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Elevated anion gap

Agents causing an elevated anion gap (METAL ACID GAP)

  • Methanol, metformin, massive overdoses
  • Ethylene glycol
  • Toluene
  • Alcoholic ketoacidosis
  • Lactic acidosis
  • Acetaminophen (large overdoses)
  • Cyanide, carbon monoxide, colchicine
  • Isoniazid, iron, ibuprofen
  • Diabetic ketoacidosis
  • Generalized seizure-producing toxins
  • Acetylsalicylic acid or other salicylates
  • Paraldehyde, phenformin
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